Regulatory B cells, interleukin-10, and atherosclerosis
نویسندگان
چکیده
منابع مشابه
Regulatory B cell-specific interleukin-10 is dispensable for atherosclerosis development in mice.
OBJECTIVE To determine the role of regulatory B cell-derived interleukin (IL)-10 in atherosclerosis. APPROACH AND RESULTS We created chimeric Ldlr(-/-) mice with a B cell-specific deficiency in IL-10, and confirmed that purified B cells stimulated with lipopolysaccharide failed to produce IL-10 compared with control Ldlr(-/-) chimeras. Mice lacking B-cell IL-10 demonstrated enhanced splenic B...
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ژورنال
عنوان ژورنال: Current Opinion in Lipidology
سال: 2015
ISSN: 0957-9672
DOI: 10.1097/mol.0000000000000220